PRIMARY STUDY
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Key Findings: This review aims to better explain the mechanism of Δ9-tetrahydrocannabinol (THC) as it binds to cannabinoid receptor 1 (CB1/CNR1) and its role in inflammation, oxidative stress, and coronary vascular disease. Results confirmed cannabis use led to an increase in myocardial infarction (MI) compared to non-users. However, CB1 antagonists may provide a therapeutic target in preventing and/or treating vascular inflammation and heart disease.
Type of Study: Meta-analysis
Study Sample Size: 157331
Study Result: Negative
Research Location(s): Denmark, Taiwan, United States
Year of Pub: 2022
Cannabinoids Studied: Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype I
Receptors Studied: CB1, CB2
Ligands Studied: Pro-inflammatory cytokines
Citation: Wei TT, et al. Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell. 2022; 185:1676-1693.e23. doi: 10.1016/j.cell.2022.04.005
Authors: Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC
