RELATED STUDY
Treatment of Ovarian Hyperstimulation Syndrome in a Mouse Model by Cannabidiol, an Angiogenesis Pathway Inhibitor
Key Findings: This study aimed to investigate the role of the endocannabinoid system and cannabidiol (CBD) on the mechanism of action in ovarian hyperstimulation syndrome (OHSS). The CBD group had a significant decrease in body and ovary weight, decreased vascular permeability, follicular count, and VEGF expression, suggesting CBD's antiangiogenic activity could be effective in counteracting the development of OHSS.
Type of Study: Animal Study
Study Sample Size: 32
Study Result: Positive
Research Location(s): Iran
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Ligands Studied: Anti-inflammatory cytokines, Estrogen, Serotonin, Pro-inflammatory cytokines
Dosage: CBD (30 mg/kg)
Route of Administration: Oral (Ingestion)
Citation: Tahermanesh K, et al. Treatment of Ovarian Hyperstimulation Syndrome in a Mouse Model by Cannabidiol, an Angiogenesis Pathway Inhibitor. Biomed Res Int. 2022; 2022:1111777. doi: 10.1155/2022/1111777
Authors: Tahermanesh K, Hakimpour S, Govahi A, Keyhanfar F, Kashi AM, Chaichian S, Shahriyaripour R, Ajdary M
