RELATED STUDY
Cannabidiol Increases Seizure Resistance and Improves Behavior in an Scn8a Mouse Model
Key Findings: In mice with SCN8A mutations cannabidiol (CBD) administration resulted in a dose-dependent increase in the resistance to seizures, as well as improvements in social and hyperactivity behaviors.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Receptors Studied: CB1, CB2, GPCR 55, TRPV1
Ligands Studied: Serotonin
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Oral (Ingestion)
Dosing Regimen: CBD (200–360 mg/kg) for seizure test CBD (10 mg/kg) for social behavior test CBD (100 mg/kg) for hyperactivity test
Clinical Relevance: The greatest protection against 6 Hz seizures was with 360 mg/kg CBD. CBD can restore more normal social discrimination.
Adverse Events: There were no motor toxicity effects with this dose of CBD.
Citation: Shapiro L, et al. Cannabidiol Increases Seizure Resistance and Improves Behavior in an Scn8a Mouse Model. Front Pharmacol. 2022; 13:815950. doi: 10.3389/fphar.2022.815950
Authors: Shapiro L, Escayg A, Wong JC
