PRIMARY STUDY
The Autism–Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System
Key Findings: This review explores the role of the endocannabinoid system in early neurobiological development and modulation of neural circuits, and how alterations could be implicated in Autism spectrum disorder (ASD), and similar neurodivergent conditions like schizophrenia and psychosis. Also reviewed are potential therapeutic targets in the treatment of these disorders.
Type of Study: Meta-analysis
Study Result: Inconclusive
Research Location(s): Italy, United Kingdom
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype I, Chemotype III
Receptors Studied: CB1, CB2
Ligands Studied: Dopamine, GABA, Glutamate, Serotonin
Citation: Colizzi M, et al. The Autism-Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System. Int J Environ Res Public Health. 2022; 19:(unknown pages). doi: 10.3390/ijerph19095616
Authors: Colizzi M, Bortoletto R, Costa R, Bhattacharyya S, Balestrieri M
