PRIMARY STUDY
Enhancement of Anandamide-Mediated Endocannabinoid Signaling Corrects Autism-Related Social Impairment
Key Findings: This mouse study of behavioral changes in a model of autism spectrum disorder (ASD) found that increased levels of anandamide via CB1 receptors improved social impairments and may present a future therapeutic target in the treatment of ASD by inhibiting fatty acid amide hydrolase (FAAH).
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China, Italy, United States
Year of Pub: 2016
Cannabinoids Studied: AM-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1
Route of Administration: Injection
Citation: Wei D, et al. Enhancement of Anandamide-Mediated Endocannabinoid Signaling Corrects Autism-Related Social Impairment. Cannabis Cannabinoid Res. 2016; 1:81-89. doi: 10.1089/can.2015.0008
Authors: Wei D, Dinh D, Lee D, Li D, Anguren A, Moreno-Sanz G, Gall CM, Piomelli D
