Key Findings:  This review of the currently available knowledge around the molecular mechanisms that regulate hippocampal regions of the brain and the influence of the endocannabinoid system offers insight into cognitive and behavioral dysfunction and potential treatment targets.
Type of Study:  Meta-analysis
Study Result:  Positive
Research Location(s):  Spain
Year of Pub:  2021
Cannabinoids Studied:  Tetrahydrocannabinol (THC), Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Endocannabinoid (unspecified)
Phytocannabinoid Source:  Not Applicable
Receptors Studied:  CB1, CB2, GPCR
Ligands Studied:  Acetylcholine, Dopamine, Endogenous opioids, GABA, Glutamate, Serotonin
Citation:  Robledo-Menendez A, et al. Cannabinoid control of hippocampal functions: the where matters. FEBS J. 2022; 289:2162-2175. doi: 10.1111/febs.15907
Authors:  Robledo-Menendez A, Vella M, Grandes P, Soria-Gomez E