PRIMARY STUDY
Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid
Key Findings: Resulting data indicates that abnormalities in anandamide activity may underlie the deleterious impact of environmental risk factors on ASD-relevant behaviors. As such, modulating components of the ECS may represent a novel therapeutic target mechanism for primary and associated symptoms common to this patient population.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2016
Cannabinoids Studied: Anandamide (AEA)
Phytocannabinoid Source: Not Applicable
Citation: Servadio M, et al. Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid. Transl Psychiatry. 2016; 6:e902. doi: 10.1038/tp.2016.182
Authors: Servadio M, Melancia F, Manduca A, di Masi A, Schiavi S, Cartocci V, Pallottini V, Campolongo P, Ascenzi P, Trezza V
