Key Findings:  This case series outlines 2 patients with septic shock who were treated with direct hemoperfusion using polymyxin B-immobilized fiber and oral vancomycin, which dramatically improved both cases. The mechanism is believed to improve the hypotension-correcting cytokine balance with adsorption of endogenous cannabinoids in serum.
Type of Study:  Meta-analysis
Study Sample Size:  2
Study Result:  Positive
Research Location(s):  Japan
Year of Pub:  2007
Cannabinoids Studied:  Endocannabinoid (unspecified)
Phytocannabinoid Source:  Not Applicable
Ligands Studied:  Pro-inflammatory cytokines
Citation:  Kimura Y, Sato K, Tokuda H, Nakamura N, Dohi Y, Orito E, Mizokami M. Effects of combination therapy with direct hemoperfusion using polymyxin B-immobilized fiber and oral vancomycin on fulminant pseudomembranous colitis with septic shock. Dig Dis Sci. 2007 Mar;52(3):675-8. doi: 10.1007/s10620-006-9494-5. PMID: 17273924.