PRIMARY STUDY
Cannabis sativa alleviates experimentally acetic acid- induced ulcerative colitis in rats: targeting CB1/SIRT/MAPK signaling pathways
Key Findings: Through CB1 receptor activation Cannabis sativa appears to inhibit the TLR-4 MAPK/ERK, PI3K, and NFκB signaling pathways, counteracting the effects of acetic acid-induced colitis in rats.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Egypt
Year of Pub: 2025
Cannabinoids Studied: Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1
Route of Administration: Injection
Citation: Elgohary R, Omara EA, Salama A. Cannabis sativa alleviates experimentally acetic acid- induced ulcerative colitis in rats: targeting CB1/SIRT/MAPK signaling pathways. Immunopharmacol Immunotoxicol. 2025 Feb;47(1):120-130. doi: 10.1080/08923973.2024.2445733. Epub 2024 Dec 25. PMID: 39721800.
