PRIMARY STUDY
Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation.
Key Findings: These studies demonstrate for the first time that FAAH-II inhibitor may suppress colitis through regulation of pro-inflammatory miRNAs expression.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2018
Cannabinoids Studied: Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH)
Phytocannabinoid Source: Not Applicable
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Citation: Shamran H, et al. Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation. Brain Behav Immun. 2017; 59:10-20. doi: 10.1016/j.bbi.2016.06.008
Authors: Shamran H, Singh NP, Zumbrun EE, Murphy A, Taub DD, Mishra MK, Price RL, Chatterjee S, Nagarkatti M, Nagarkatti PS, Singh UP
