Key Findings:  In a study of healthy volunteers, dronabinol, a nonselective cannabinoid receptor agonist, was found to relax the colon and reduce postprandial colonic motility and tone, while increasing pain sensation during colonic distension, indicating potential central modulation of perception and suggesting further research into its role in modulating colonic motor function in conditions like irritable bowel syndrome.
Type of Study:  Double Blind Clinical Trial
Study Sample Size:  52
Study Result:  Negative
Research Location(s):  United States
Year of Pub:  2007
Cannabinoids Studied:  Pharma THC
Phytocannabinoid Source:  Not Applicable
Route of Administration:  Oral (Ingestion)
Citation:  Esfandyari T, et al. Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study. Am J Physiol Gastrointest Liver Physiol. 2007; 293:G137-45. doi: 10.1152/ajpgi.00565.2006
Authors:  Esfandyari T, Camilleri M, Busciglio I, Burton D, Baxter K, Zinsmeister AR