PRIMARY STUDY
Cutaneous Application of Capsaicin Cream Reduces Clinical Signs of Experimental Colitis and Repairs Intestinal Barrier Integrity by Modulating the Gut Microbiota and Tight Junction Proteins
Key Findings: Topical capsaicin shows a potential novel therapeutic use for reducing inflammation and oxidation related to gastrointestinal colitis.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Brazil, France
Year of Pub: 2024
Cannabinoids Studied: Microbiome, Capsaicin (CAPS)
Phytocannabinoid Source: Not Applicable
Route of Administration: Topical
Citation: Santos EA, et al. Cutaneous Application of Capsaicin Cream Reduces Clinical Signs of Experimental Colitis and Repairs Intestinal Barrier Integrity by Modulating the Gut Microbiota and Tight Junction Proteins. ACS Pharmacol Transl Sci. 2024; 7:2143-2153. doi: 10.1021/acsptsci.4c00207
Authors: Santos EA, Silva JL, Leocádio PCL, Andrade MER, Queiroz-Junior CM, Oliveira NSS, Alves JL, Oliveira JS, Aguilar EC, Boujour K, Cogliati B, Cardoso VN, Fernandes SOA, Faria AMC, Alvarez-Leite JI
