PRIMARY STUDY
Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system
Key Findings: Resveratrol ameliorated the effects of a high-fat diet in test animals. More specifically, resveratrol inhibited high-fat-diet-induced elevation in the expression of CB1 mRNA. It also suppressed CB2 mRNA levels in the colon. Both effects were associated with enhanced gut barrier integrity and reduced intestinal permeability.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China
Year of Pub: 2020
Cannabinoids Studied: Resveratrol
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2
Route of Administration: Oral (Ingestion)
Citation: Chen M, et al. Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system. Clin Nutr. 2020; 39:1264-1275. doi: 10.1016/j.clnu.2019.05.020
Authors: Chen M, Hou P, Zhou M, Ren Q, Wang X, Huang L, Hui S, Yi L, Mi M
