RELATED STUDY
Cannabidiol-Loaded Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Paclitaxel-Induced Peripheral Neuropathy
Key Findings: This mouse and lab model of chemotherapy-induced peripheral neuropathy (CIPN) by paclitaxel found that cannabidiol (CBD) in extracellular vesicles (EV) reduced mechanical and thermal hypersensitivity better than CBD alone or EV alone. Results hypothesize that CBD-EVs may present an effective treatment option for cancer patients with for CIPN.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2023
Cannabinoids Studied: Cannabidiol (CBD), Pharma THC
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Receptors Studied: CB1, CB2
Ligands Studied: Serotonin
Dosage: CBD (5mg/kg)
Route of Administration: In vitro, Injection
Citation: Kalvala AK, et al. Cannabidiol-Loaded Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Paclitaxel-Induced Peripheral Neuropathy. Pharmaceutics. 2023; 15:(unknown pages). doi: 10.3390/pharmaceutics15020554
Authors: Kalvala AK, Bagde A, Arthur P, Kulkarni T, Bhattacharya S, Surapaneni S, Patel NK, Nimma R, Gebeyehu A, Kommineni N, Meckes DG, Sun L, Banjara B, Mosley-Kellum K, Dinh TC, Singh M
