PRIMARY STUDY
Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
Key Findings: In this study of mice intestinal inflammation and hypermobility found that the endocannabinoid plays a role in this process and that cannabichromene (CBC) reduced inflammation and was not dependent on the cannabinoid receptors or TRPA1
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2012
Cannabinoids Studied: Cannabichromene (CBC), Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Unspecified
Receptors Studied: CB1, CB2, TRPA1, CB1 antagonist, CB2 antagonist
Route of Administration: Injection
Citation: Izzo AA, et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol. 2012; 166:1444-60. doi: 10.1111/j.1476-5381.2012.01879.x
Authors: Izzo AA, Capasso R, Aviello G, Borrelli F, Romano B, Piscitelli F, Gallo L, Capasso F, Orlando P, Di Marzo V
