RELATED STUDY
Cannabinoid 1 and mu-Opioid Receptor Agonists Synergistically Inhibit Abdominal Pain and Lack Side Effects in Mice
Key Findings: The cannabinoid 1 receptor (CB1R) agonists (arachidonyl-2′-chloroethylamide (ACEA) and HU-210) alone and in combination with opioids effectively decreased visceromotor responses (VMR) and colonic nerve mechanosensitivity in mice suggesting potential novel therapeutic uses for cannabinoids in treating certain types of abdominal pain.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Canada
Year of Pub: 2022
Cannabinoids Studied: HU-x Synthetic Cannabinoids, Synthetic Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, Opioid Receptor Mu , Opioid Receptor Nociceptin
Citation: Yu Y, et al. Cannabinoid 1 and mu-Opioid Receptor Agonists Synergistically Inhibit Abdominal Pain and Lack Side Effects in Mice. J Neurosci. 2022; 42:6313-6324. doi: 10.1523/JNEUROSCI.0641-22.2022
Authors: Yu Y, Tsang QK, Jaramillo-Polanco J, Lomax AE, Vanner SJ, Reed DE
