PRIMARY STUDY
Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice
Key Findings: This study of the endocannabinoid system and gut inflammation using a mouse model of inflammatory bowel disease (IBD) found that inhibiting fatty acid amide hydrolase (FAAH) through genetic variation was effective in reducing inflammation, and may provide future therapeutic targets for the treatment of the disease.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Canada, Spain, United States
Year of Pub: 2021
Cannabinoids Studied: Tetrahydrocannabinol (THC), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Citation: Vecchiarelli HA, et al. Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice. Front Cell Neurosci. 2021; 15:764706. doi: 10.3389/fncel.2021.764706
Authors: Vecchiarelli HA, Aukema RJ, Hume C, Chiang V, Morena M, Keenan CM, Nastase AS, Lee FS, Pittman QJ, Sharkey KA, Hill MN
