PRIMARY STUDY
Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase
Key Findings: This murine study found that alterations of the endocannabinoid levels, specifically anandamide (AEA) and fatty acid amide hydrolase (FAAH), had an effect on anxiety and depression symptoms, and targeting the ECS may provide novel therapeutics for colitis-associated psychiatric symptoms.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Canada
Year of Pub: 2021
Cannabinoids Studied: Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Virodhamine (O-AEA), Cannabinoid (unspecified), Endocannabinoid (unspecified), Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, TRPV1, PPARs
Citation: Vecchiarelli HA, et al. Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase. Neuropsychopharmacology. 2021; 46:992-1003. doi: 10.1038/s41386-020-00939-7
Authors: Vecchiarelli HA, Morena M, Keenan CM, Chiang V, Tan K, Qiao M, Leitl K, Santori A, Pittman QJ, Sharkey KA, Hill MN
