PRIMARY STUDY
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
Key Findings: This study of colon inflammation found that anandamide (AEA) levels are elevated in human ulcerative colitis samples, as well as animal inflammatory bowel disease (IBD) models. By increasing AEA levels and inhibiting its reuptake the anti-inflammation effects of the endocannabinoid system may lead be novel therapeutic agents for the treatment of these gastrointestinal conditions.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2006
Cannabinoids Studied: Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Endocannabinoid (unspecified)
Phytocannabinoid Source: Unspecified
Receptors Studied: CB1, CB2, TRPV1, TRPs
Ligands Studied: Serotonin
Route of Administration: In vitro, Injection
Citation: D'Argenio G, et al. Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. FASEB J. 2006; 20:568-70. doi: 10.1096/fj.05-4943fje
Authors: D'Argenio G, Valenti M, Scaglione G, Cosenza V, Sorrentini I, Di Marzo V
