PRIMARY STUDY
Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon.
Key Findings: Palmitoylethanolamide (PEA) and CBD are anti-inflammatory in the human colon. This effect is not seen in cultured epithelial cells. Appropriately sized clinical trials should assess their efficacy.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): United Kingdom
Year of Pub: 2017
Cannabinoids Studied: Cannabidiol (CBD), AM-x Synthetic Cannabinoids, Synthetic Cannabinoid (unspecified), Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Not Applicable
Chemotype: Chemotype III
Receptors Studied: CB1, CB2, GPCR 55, TRPV1, PPAR - Gamma
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Route of Administration: In vitro
Citation: Couch DG, et al. Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon. Clin Sci (Lond). 2017; 131:2611-2626. doi: 10.1042/CS20171288
Authors: Couch DG, Tasker C, Theophilidou E, Lund JN, O'Sullivan SE
