PRIMARY STUDY
Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production
Key Findings: Resulting data revealed that THC (via activation of CB2) is a potent suppressor of aberrant immune responses by provoking coordination between APCs and T regulatory cells and as such attenuates colitis-associated colon cancer and colitis induced by anti-CD40.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2020
Cannabinoids Studied: Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype I
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Route of Administration: Oral (Ingestion)
Citation: Becker W, et al. Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production. iScience. 2020; 23:101504. doi: 10.1016/j.isci.2020.101504
Authors: Becker W, Alrafas HR, Wilson K, Miranda K, Culpepper C, Chatzistamou I, Cai G, Nagarkatti M, Nagarkatti PS
