PRIMARY STUDY
Cannabinoid receptor activation on hematopoietic cells and enterocytes protects against colitis
Key Findings: Test animals received either CBD, Δ 9-THC, a combination of CBD and THC or vehicle. Resulting data revealed that THC prevented colitis via activation of CB2 (independent of changes to the microbiome) while CBD (at the dosages tested) alone or in combination induced little benefit.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2020
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype I, Chemotype II, Chemotype III
Receptors Studied: CB2
Route of Administration: Injection
Citation: Becker W, et al. Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis. J Crohns Colitis. 2021; 15:1032-1048. doi: 10.1093/ecco-jcc/jjaa253
Authors: Becker W, Alrafas HR, Busbee PB, Walla MD, Wilson K, Miranda K, Cai G, Putluri V, Putluri N, Nagarkatti M, Nagarkatti PS
