PRIMARY STUDY
Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH)
Key Findings: Using an FAAH inhibitor (PF-3845) researchers discovered that FAAH-dependent endocannabinoids play a significant role in colitis.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Germany, Poland, United States
Year of Pub: 2014
Cannabinoids Studied: AM-x Synthetic Cannabinoids, Fatty Acid Amide Hydrolase (FAAH), Synthetic Cannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Citation: Sałaga M, et al. Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH). J Crohns Colitis. 2014; 8:998-1009. doi: 10.1016/j.crohns.2014.01.025
Authors: Sałaga M, Mokrowiecka A, Zakrzewski PK, Cygankiewicz A, Leishman E, Sobczak M, Zatorski H, Małecka-Panas E, Kordek R, Storr M, Krajewska WM, Bradshaw HB, Fichna J
