PRIMARY STUDY

Combination of CBD with minor cannabinoid CBDV suppresses CXCR4 via CB2 receptor and alleviates colitis in mice

Key Findings:  In mice, the combination of cannabidiol (CBD) and cannabidivarin (CBDV) significantly reduced C-X-C chemokine receptor type 4 (CXCR4) expression, a critical chemokine in immune cells implicated in inflammatory bowel disease (IBD). These results further support the role of the endocannabinoid system in downregulating CXCR4.