PRIMARY STUDY
Crosstalk between M1 muscarinic acetylcholine receptor and endocannabinoid system promotes attenuation of inflammation in ulcerative colitis
Key Findings: This mouse model of ulcerative colitis finds that CB1 and CB2 receptors are involved in the anti-inflammatory action of McN-A-343, the agonist M1 receptor. AM251 or AM630, before treatment with McN-A-343, significantly altered the anti-inflammatory response.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Brazil
Year of Pub: 2025
Cannabinoids Studied: AM-x Synthetic Cannabinoids, Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1
Citation: de Aguiar Magalhães D, Guimarães Sousa S, da Silva Monteiro CE, Arruda Batista J, de Sousa AK, Dos Santos Ferreira J, Carvalho Pereira CM, do Nascimento Lima JV, da Silva Sousa JJ, da Silva Prudêncio R, Lino da Silva TM, Oliveira Silva FG, Franco AX, Di Lenardo D, Pereira Vasconcelos DF, Almeida Rocha J, Alves Figueiredo K, Gomes Soares PM, Dos Reis Barbosa AL. Crosstalk between M1 muscarinic acetylcholine receptor and endocannabinoid system promotes attenuation of inflammation in ulcerative colitis. Eur J Pharmacol. 2025 Dec 5;1008:178368. doi: 10.1016/j.ejphar.2025.178368. Epub 2025 Nov 13. PMID: 41241333.
