RELATED STUDY
The Endocannabinoid-Microbiota-Neuroimmune Super-System: A Unifying Feedback Architecture for Systems Resilience, Collapse Trajectories, and Precision Feedback Medicine
Key Findings: This extensive review discusses the Endocannabinoid–Microbiota–Neuroimmune Super-System (EMN-S) and how each interacts through feedback control, and aims to shift the focus to pathophysiology rather than models of systemic derangements.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Romania
Year of Pub: 2025
Cannabinoids Studied: Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Endocannabinoid (unspecified), Palmitoylethanolamide (PEA), Microbiome, Oleoylethanolamide (OEA)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, GPCR 18, GPCR 55, TRPV1, PPAR - Alpha, PPAR - Gamma, PPARs
Ligands Studied: Anti-inflammatory cytokines, Dopamine, GABA, Serotonin, Pro-inflammatory cytokines
Citation: Aliuș C, Breazu A, Pantu C, Toader C, Șerban M, Covache-Busuioc RA, Munteanu O, Dumitru AV. The Endocannabinoid-Microbiota-Neuroimmune Super-System: A Unifying Feedback Architecture for Systems Resilience, Collapse Trajectories, and Precision Feedback Medicine. Int J Mol Sci. 2025 Nov 12;26(22):10959. doi: 10.3390/ijms262210959. PMID: 41303442; PMCID: PMC12652726.
