PRIMARY STUDY

Interleukin 17A evoked mucosal damage is attenuated by cannabidiol and anandamide in a human colonic explant model

Key Findings:  This study demonstrates that IL-17A is widely expressed in the human colon and can directly induce mucosal epithelial damage via matrix metalloprotease activation, an effect attenuated by anandamide and cannabidiol, supporting a protective role for cannabinoid ligands in inflammatory bowel disease.