PRIMARY STUDY
β-Caryophyllene Acts as a Ferroptosis Inhibitor to Ameliorate Experimental Colitis
Key Findings: This study demonstrates that β-caryophyllene attenuates experimental ulcerative colitis by activating CB2 receptors to inhibit macrophage ferroptosis, thereby reducing lipid peroxidation–driven inflammatory responses both in vivo and in vitro.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China
Year of Pub: 2026
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2
Route of Administration: , Oral (Ingestion)
Citation: Wu YT, Zhong LS, Huang C, Guo YY, Jin FJ, Hu YZ, Zhao ZB, Ren Z, Wang YF. β-Caryophyllene Acts as a Ferroptosis Inhibitor to Ameliorate Experimental Colitis. Int J Mol Sci. 2022 Dec 16;23(24):16055. doi: 10.3390/ijms232416055. PMID: 36555694; PMCID: PMC9784863.
