RELATED STUDY

Intestinal inflammation-associated hypersensitivity is attenuated in a DSS model of colitis in Sigma-1 knockout C57BL/6 mice

Key Findings:  This hypersensitivity model of colitis in σ1R knockout (KO) mice found similar changes in the colonic expression of nociceptive markers during the acute and chronic phases of inflammation, compared to wild-type mice. These differences were especially relevant for CB2 and TRPV1 receptors, which could point to the role in σ1-mediated regulation of sensitivity