PRIMARY STUDY
Effect of N-palmitoylethanolamine-oxazoline on comorbid neuropsychiatric disturbance associated with inflammatory bowel disease
Key Findings: This rat model of colitis demonstrated the effect of N-Palmitoylethanolamine-oxazoline (PEA-OXA) on the gut-brain axis and its implication on the “secondary” effects associated with colonic disturbance.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy, United States
Year of Pub: 2020
Cannabinoids Studied: Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Not Applicable
Citation: Cordaro M, Scuto M, Siracusa R, D'amico R, Filippo Peritore A, Gugliandolo E, Fusco R, Crupi R, Impellizzeri D, Pozzebon M, Alfonsi D, Mattei N, Marcolongo G, Evangelista M, Cuzzocrea S, Di Paola R. Effect of N-palmitoylethanolamine-oxazoline on comorbid neuropsychiatric disturbance associated with inflammatory bowel disease. FASEB J. 2020 Mar;34(3):4085-4106. doi: 10.1096/fj.201901584RR. Epub 2020 Jan 16. Erratum in: FASEB J. 2024 Mar 15;38(5):e23503. doi: 10.1096/fj.202400297. PMID: 31950563.
