PRIMARY STUDY
Involvement of cannabinoid receptors and neuroinflammation in early sepsis: Implications for posttraumatic stress disorder
Key Findings: Induced CB1 blockade, with the CB1 antagonist antagonists AM251, increased survival and reversed the fear memory generalization in rats with post-traumatic stress disorder and neuroinflammation following septic infection. Treatment with the CB2 antagonist, AM630, also reversed the generalization of fear memory but did not increase survival.
Type of Study: Clinical Trial
Study Result: Positive
Research Location(s): Brazil
Year of Pub: 2023
Cannabinoids Studied: Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Synthetic Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, CB2, GPCR, CB1 agonist, CB1 antagonist, CB2 agonist, CB2 antagonist
Ligands Studied: Epinephrine, Norepinephrine, Serotonin, Pro-inflammatory cytokines
Citation: Matias ME, et al. Involvement of cannabinoid receptors and neuroinflammation in early sepsis: Implications for posttraumatic stress disorder. Int Immunopharmacol. 2023; 123:110745. doi: 10.1016/j.intimp.2023.110745
Authors: Matias ME, Radulski DR, Rodrigues da Silva T, Raymundi AM, Stern CAJ, Zampronio AR
