PRIMARY STUDY
CB2 Cannabinoid Receptors Contribute to Bacterial Invasion and Mortality in Polymicrobial Sepsis.
Key Findings: Taken together, our results establish for the first time that CB2 receptors are important contributors to septic immune dysfunction and mortality, indicating that CB2 receptors may be therapeutically targeted for the benefit of patients suffering from sepsis.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2009
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Citation: Csóka B, et al. CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis. PLoS One. 2009; 4:e6409. doi: 10.1371/journal.pone.0006409
Authors: Csóka B, Németh ZH, Mukhopadhyay P, Spolarics Z, Rajesh M, Federici S, Deitch EA, Bátkai S, Pacher P, Haskó G
