PRIMARY STUDY
The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats
Key Findings: CB2 agonism (via JWH-133) decreases inflammation, and reduces the damage in brain, lung, liver and heart. JWH-133 reduced pro-inflammatory cytokines caspase-3, p-NF-κB, TNF-α, IL-1β, IL-6 levels and increased the anti-inflammatory cytokine IL-10 levels.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Turkey
Year of Pub: 2020
Cannabinoids Studied: JWH-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Citation: Çakır M, et al. The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats. Int Immunopharmacol. 2020; 78:105978. doi: 10.1016/j.intimp.2019.105978
Authors: Çakır M, Tekin S, Okan A, Çakan P, Doğanyiğit Z
