PRIMARY STUDY
Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid
Key Findings: Results show the ability of HU-211 to suppress inflammatory cytokines (TNFalpha) production and to rescue mice and rats from endotoxic shock. HU-211 may, therefore, have therapeutic implications in the treatment of TNFalpha-mediated pathologies.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Israel
Year of Pub: 1997
Cannabinoids Studied: HU-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Dosage: HU-211, administered i.p. 30 min before lipopolysaccharide (LPS), significantly reduced lethality in the test animals.
Route of Administration: Injection
Citation: Gallily R, et al. Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. J Pharmacol Exp Ther. 1997; 283:918-24.
Authors: Gallily R, Yamin A, Waksmann Y, Ovadia H, Weidenfeld J, Bar-Joseph A, Biegon A, Mechoulam R, Shohami E
