PRIMARY STUDY

Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review

Key Findings:  This systematic review of gene × environment interactions in bipolar disorder (BD) and schizophrenia spectrum phenotypes, finds consistently that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia spectrum disorders and BD..