PRIMARY STUDY

Antipsychotic-like effects of cannabidiol and rimonabant: systematic review of animal and human studies

Key Findings:  A systematic review of animal models and clinical trials suggests that pharmacological manipulation of the endocannabinoid system, particularly through agents like cannabidiol and rimonabant, may exhibit antipsychotic properties, with cannabidiol showing a favorable profile similar to atypical antipsychotic drugs, potentially due to its interaction with elevated anandamide levels and counteraction of psychosis-related cognitive impairments.