PRIMARY STUDY
Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment
Key Findings: Alterations in dopamine receptors in the methylazoxymethanol acetate (MAM) model in rats suggests that it might not only contribute to the schizophrenia symptoms but also represent an potential future target via dopamine receptors and GPCRs for the antipsychotic activity of cannabidiol.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Canada, Czech Republic, Germany, Israel, Italy, Russia
Year of Pub: 2020
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Receptors Studied: GPCR
Ligands Studied: Dopamine
Dosage: Cannabidiol (30 mg/kg)
Citation: Stark T, et al. Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment. Biochem Pharmacol. 2020; 177:114004. doi: 10.1016/j.bcp.2020.114004
Authors: Stark T, Di Bartolomeo M, Di Marco R, Drazanova E, Platania CBM, Iannotti FA, Ruda-Kucerova J, D'Addario C, Kratka L, Pekarik V, Piscitelli F, Babinska Z, Fedotova J, Giurdanella G, Salomone S, Sulcova A, Bucolo C, Wotjak CT, Starcuk Z, Drago F, Mechoulam R, Di Marzo V, Micale V
