PRIMARY STUDY

Ventral hippocampal overexpression of Cannabinoid Receptor Interacting Protein 1 (CNRIP1) produces a schizophrenia-like phenotype in the rat

Key Findings:  The authors of this study write: "Adolescent cannabis use has been implicated as a risk factor for schizophrenia; however, it is neither necessary nor sufficient." They further suggest that these present study results provide evidence that alterations in cannabinoid receptor interacting protein 1 (CNRIP1) may contribute to the pathophysiology of schizophrenia, as overexpression is sufficient to produce neurophysiological and behavioral correlates consistently observed in rodent models of the disease.