PRIMARY STUDY

Neuroimaging studies of acute effects of THC and CBD in humans and animals: a systematic review

Key Findings:  This systematic review, including 45 studies from a pool of 224, assesses the impact of acute cannabis exposure on brain function, revealing that THC and CBD typically exert opposite neurophysiological effects on brain activity in humans and animals, with no strong evidence supporting increased dopaminergic activity in THC-induced psychosis, highlighting the need for more standardized methodologies and replication in future neuroimaging studies.