PRIMARY STUDY
Preliminary report of biological basis of sensitivity to the effects of cannabis on psychosis: AKT1 and DAT1 genotype modulates the effects of δ-9-tetrahydrocannabinol on midbrain and striatal function
Key Findings: This study finds that the acute psychotogenic effects of tetrahydrocannabinol are moderated by two genotypes, AKT1 and DAT1, which affect the proteins required for dopamine metabolism and modulate the effects of THC on the function of the midbrain and striatal brain regions.
Type of Study: Clinical Trial
Study Result: Inconclusive
Research Location(s): Brazil, Spain, United Kingdom
Year of Pub: 2012
Cannabinoids Studied: Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype I
Citation: Bhattacharyya S, et al. Preliminary report of biological basis of sensitivity to the effects of cannabis on psychosis: AKT1 and DAT1 genotype modulates the effects of δ-9-tetrahydrocannabinol on midbrain and striatal function. Mol Psychiatry. 2012; 17:1152-5. doi: 10.1038/mp.2011.187
Authors: Bhattacharyya S, Atakan Z, Martin-Santos R, Crippa JA, Kambeitz J, Prata D, Williams S, Brammer M, Collier DA, McGuire PK
