PRIMARY STUDY
Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis
Key Findings: In patients with clinical high risk for psychosis (CHR), compared to healthy subjects, a single dose of cannabidiol (CBD) reduced the activity in the left insula/parietal operculum and slowed of reaction time, suggesting CBD may be a useful therapeutic agent in treating dysfunction related to CHR.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 52
Study Result: Positive
Research Location(s): Netherlands, United States
Year of Pub: 2019
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Not Applicable
Chemotype: Chemotype III
Receptors Studied: CB1, GPCR
Ligands Studied: Dopamine, Glutamate
Route of Administration: Oral (Ingestion)
Citation: Wilson R, et al. Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis. Transl Psychiatry. 2019; 9:203. doi: 10.1038/s41398-019-0534-2
Authors: Wilson R, Bossong MG, Appiah-Kusi E, Petros N, Brammer M, Perez J, Allen P, McGuire P, Bhattacharyya S
