PRIMARY STUDY
Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report
Key Findings: This study investigated whether treatment with cannabidiol (CBD) in patients with Clinical High Risk for Psychosis (CHR) could normalize alterations in the cortisol regulation of fear response and found that compared to placebo, the group receiving CBD had an intermediate level of deactivation in the fear response region of the brain.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 16
Study Result: Positive
Research Location(s): Netherlands, United Kingdom
Year of Pub: 2021
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Ligands Studied: Cortisol
Dosage: CBD (600 mg)
Route of Administration: Oral (Ingestion)
Citation: Davies C, et al. Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report. Eur Arch Psychiatry Clin Neurosci. 2022; 272:461-475. doi: 10.1007/s00406-021-01318-z
Authors: Davies C, Appiah-Kusi E, Wilson R, Blest-Hopley G, Bossong MG, Valmaggia L, Brammer M, Perez J, Allen P, Murray RM, McGuire P, Bhattacharyya S
