PRIMARY STUDY
Opposite Roles for Cannabidiol and δ-9-Tetrahydrocannabinol in Psychotomimetic Effects of Cannabis Extracts: A Naturalistic Controlled Study
Key Findings: This study confirms the psychomimetic effects of THC and the antipsychotomimetic effects of CBD and provides further evidence of the link between the endocannabinoid system and psychosis showing that CBD can lessen the psychomimetic effects when given with THC. This provides potential future options for the treatment of psychosis disorders such as schizophrenia.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 18
Study Result: Positive
Research Location(s): Netherlands, Spain
Year of Pub: 2021
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Unspecified
Citation: Sainz-Cort A, et al. Opposite Roles for Cannabidiol and δ-9-Tetrahydrocannabinol in Psychotomimetic Effects of Cannabis Extracts: A Naturalistic Controlled Study. J Clin Psychopharmacol. 2021; 41:561-570. doi: 10.1097/JCP.0000000000001457
Authors: Sainz-Cort A, Jimenez-Garrido D, Muñoz-Marron E, Viejo-Sobera R, Heeroma J, Bouso JC
