Key Findings: Animal trials suggest that the effects of CBD depend on dose, strain, can vary in acute and chronic setting, and with different form of administration. CBD is posited to induce its effects via CB1, CB2, 5-HT1A receptor sites and neurogenesis factors. Early clinical trials support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant, and a positive risk-benefit profile.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Spain
Year of Pub: 2020
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Receptors Studied: CB1, CB2
Ligands Studied: Serotonin
Citation: García-Gutiérrez MS, et al. Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders. Biomolecules. 2020; 10:(unknown pages). doi: 10.3390/biom10111575
Authors: García-Gutiérrez MS, Navarrete F, Gasparyan A, Austrich-Olivares A, Sala F, Manzanares J