PRIMARY STUDY

Increased BDNF-TrkB signaling in the nucleus accumbens plays a role in the risk for psychosis after cannabis exposure during adolescence

Key Findings:  In this study, researchers examined which specific molecular mechanisms may be involved in producing the potentially increased risk of psychosis. More specifically they examined whether brain-derived neurotrophic factor (BDNF) and its receptor TrkB signaling plays a role in the risk for psychosis in adolescence using cannabis. Results showed that TrkB antagonists may produce protective effects.