PRIMARY STUDY
Cannabinoid use is enhanced by stress and changes conditioned stress responses
Key Findings: Cannabis self-administration (THC + CBD) in stressed rats altered conditioned stress responses by increasing the salience of neutral cues, which promoted active behaviors like drug seeking, while stress-associated cues inhibited drug seeking and induced passive coping behaviors, suggesting cannabis may exacerbate conditioned stress responses.
Type of Study: Animal Study
Study Result: Inconclusive
Research Location(s): United States
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype II
Route of Administration: Oral (Ingestion)
Citation: Hodebourg R, et al. Cannabinoid use is enhanced by stress and changes conditioned stress responses. Neuropsychopharmacology. 2022; 47:1037-1045. doi: 10.1038/s41386-022-01287-4
Authors: Hodebourg R, Meyerink ME, Crow AD, Reichel CM, Kalivas PW, Garcia-Keller C
