PRIMARY STUDY
Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next?
Key Findings: Most of the available research on cannabinoid use in post-traumatic stress disorder (PTSD) involves animal models, and cannot yet be adequately translated to humans. This review argues that cannabinoids, endocannabinoids, and the endocannabinoid system (ECS) could be promising targets for improving symptomology among human PTSD patients.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Australia, Sweden, United States
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Cannabinoid (unspecified)
Phytocannabinoid Source: Unspecified
Ligands Studied: Cortisol, Serotonin
Citation: Ney LJ, et al. Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next?. Neurosci Biobehav Rev. 2022; 132:76-91. doi: 10.1016/j.neubiorev.2021.11.040
Authors: Ney LJ, Crombie KM, Mayo LM, Felmingham KL, Bowser T, Matthews A
