PRIMARY STUDY
Cannabis oil in treating Parkinson's disease: improvement of motor and non-motor symptoms: a case report
Key Findings: This case report details a case of a 77-year-old man with advanced Parkinson's Disease, who, after starting treatment with Cannabis sativa oil, regained mobility, improved his oral intake, significantly improved non-motor symptoms and affect. Further research is warranted into the potential of cannabis based medicines to offer valuable and effective therapeutic targets for individuals with Parkinson's disease.
Type of Study: Meta-analysis
Study Sample Size: 1
Study Result: Positive
Research Location(s): Brazil
Year of Pub: 2025
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), Cannabinoid (unspecified), Endocannabinoid (unspecified)
Phytocannabinoid Source: Isolate
Chemotype: Chemotype III
Receptors Studied: CB1, GPCR 55, TRPV1
Ligands Studied: Dopamine, Serotonin
DOSING DETAILS 
Study Dosing Objective: Effective Dose, Safety Profile,
Established Protocol: Effective dose
Cannabinoid Ratio: (CBD : THC) 0 : 0 
Dosage Form: Full-spectrum CBD-rich oil containing THC and other phytocannabinoids, with a concentration of 20 mg/ml de CBD
Titration: first day: one drop orally twice a day second day: two drops twice daily third day: three drops twice daily tenth day: four drops twice daily one month: five drops twice daily
Additional Notes: Dose Titration
Citation: Issa CTMI, Castro RD, Albuquerque KLGD. Cannabis oil in treating Parkinson's disease: improvement of motor and non-motor symptoms: a case report. Braz J Biol. 2025 Jan 17;84:e290305. doi: 10.1590/1519-6984.290305. PMID: 39841751.
