PRIMARY STUDY
Effects of Cannabidiol on Parkinson's Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis
Key Findings: This mouse model of Parkinson's Disease (PD) found that cannabidiol significantly improved motor function, and protected areas of the brain, and appears to work via mechanisms of the gut-brain axis and different metabolic pathways.
Type of Study: Animal Study
Study Sample Size: 22
Study Result: Positive
Research Location(s): China
Year of Pub: 2022
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype III
Ligands Studied: Dopamine
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Injection
Cannabinoid Ratio: (CBD) 0 
Dosing Regimen: CBD (4.3 mg/kg/day)
Clinical Relevance: CBD could attenuate PD via the neuroprotective effect on the midbrain.
Additional Notes: Dose Affects Drug Pathways/Metabolism
Citation: Zhao J, et al. Effects of Cannabidiol on Parkinson's Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis. Evid Based Complement Alternat Med. 2022; 2022:1525113. doi: 10.1155/2022/1525113
Authors: Zhao J, Gao X, Zhao L, Wang Y, Zhang J, Liu S
