Key Findings: Intraoral CBD was effective in reducing pain, muscle tension, and bruxing activity in individuals with sleep bruxism and muscle-related Temporomandibular disorders. The 10% CBD formulation demonstrated superior results compared to 5% CBD.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 60
Study Result: Positive
Research Location(s): Poland
Year of Pub: 2024
Cannabinoids Studied: Cannabidiol (CBD), Pharma CBD
Phytocannabinoid Source: Cannabis Flower derived
Chemotype: Chemotype III
DOSING DETAILS
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Oral (Ingestion)
Cannabinoid Ratio: (CBD) 1
Dosage Form: 100% CBD isolate in powder form with hydrogel, based on hydroxyethyl cellulose (Celugel, Actifarm, Permit No 30050), to achieve polymeric gels with CBD concentrations: 5% and 10%, respectively
Dosing Regimen: Groups 1a and 1b received CBD formulations at concentrations of 10% and 5% - 10% CBD gel, the patients used 20 mg (0.02 g) CBD per side, i.e., 40 mg CBD daily, before bedtime. - 5% CBD gel applied 20 mg (0.02 g) CBD daily. Group 2 received a placebo
Clinical Relevance: Intraoral CBD application resulted in a statistically significant reduction in muscle tension, the intensity of sleep bruxism, and pain.
Additional Notes: Parallel Dose Comparison
Citation: Walczyńska-Dragon K, et al. Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity-A Randomized, Double-Blind Clinical Trial. J Clin Med. 2024; 13:(unknown pages). doi: 10.3390/jcm13051417
Authors: Walczyńska-Dragon K, Kurek-Górecka A, Niemczyk W, Nowak Z, Baron S, Olczyk P, Nitecka-Buchta A, Kempa WM