PRIMARY STUDY

Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity-A Randomized, Double-Blind Clinical Trial

Key Findings:  Intraoral CBD was effective in reducing pain, muscle tension, and bruxing activity in individuals with sleep bruxism and muscle-related Temporomandibular disorders. The 10% CBD formulation demonstrated superior results compared to 5% CBD.

Type of Study:  Double Blind Clinical Trial

Study Sample Size:  60

Study Result:  Positive

Research Location(s):  Poland

Year of Pub:  2024


Cannabinoids Studied:  Cannabidiol (CBD), Pharma CBD

Phytocannabinoid Source:  Cannabis Flower derived

Chemotype:  Chemotype III

DOSING DETAILS   

Study Dosing Objective:  Effective Dose

Established Protocol:  Effective dose

Route of Administration:  Oral (Ingestion)

Cannabinoid Ratio:  (CBD)   1    

Dosage Form:  100% CBD isolate in powder form with hydrogel, based on hydroxyethyl cellulose (Celugel, Actifarm, Permit No 30050), to achieve polymeric gels with CBD concentrations: 5% and 10%, respectively

Dosing Regimen:  Groups 1a and 1b received CBD formulations at concentrations of 10% and 5% - 10% CBD gel, the patients used 20 mg (0.02 g) CBD per side, i.e., 40 mg CBD daily, before bedtime. - 5% CBD gel applied 20 mg (0.02 g) CBD daily. Group 2 received a placebo

Clinical Relevance:  Intraoral CBD application resulted in a statistically significant reduction in muscle tension, the intensity of sleep bruxism, and pain.

Additional Notes:  Parallel Dose Comparison




Citation:  Walczyńska-Dragon K, et al. Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity-A Randomized, Double-Blind Clinical Trial. J Clin Med. 2024; 13:(unknown pages). doi: 10.3390/jcm13051417

Authors:  Walczyńska-Dragon K, Kurek-Górecka A, Niemczyk W, Nowak Z, Baron S, Olczyk P, Nitecka-Buchta A, Kempa WM